Endocrine Abstracts

Objective: With the progress of neuroendoscopic surgery in recent years, the application of endoscopy to transnasal surgery for pituitary tumors is increasing. At our institution, endonasal surgery using an endoscope alone (eTSS) has been performed in 825 patients with pituitary adenomas since November 2001. Among them, 156 patients (18.9%) had GH-secreting pituitary adenoma (GHoma), so the outcome and complications of eTSS-treated GHomas were investigated in the present study...

Introduction: Thyroglobulin (Tg) is stored in the follicular lumen of the thyroid and serves as a substrate of thyroid hormone biosynthesis. However, it was shown that Tg significantly induces thyrocyte cell growth and suppresses expression of thyroid-functional genes. Despite having such functions, molecular mechanisms of Tg action are largely unclear. We have recently demonstrated that TSH-induced thyroid cell growth is partly mediated by a downregulation of microRNAs (miRNA...